Antham is a violent and unusual love story of a ruthless contract killer. Raghav (Nagarjuna) falls in love with Bhavna (Urmila Matondkar) but hides his identity fearing that she won''t accept his love. Bhavna''s brother Inspector Krishna (Salim Ghouse) is assigned to solve a murder case committed by Raghav. The story climaxes with Raghav''s shocking identity revelation to Bhavna.